7/31/2023 0 Comments Nocturnal lagophthalmos herbal![]() The overall quality of the evidence was low for the various OTC artificial tear formulations compared in this review. Without the results of these trials, the effects of the OTC artificial tears that they evaluated are unknown. These trials may have enrolled 2079 total participants for whom no data are available. We also identified an additional 18 potentially eligible trials that were registered, but did not provide any results or publications. The literature also shows that OTC artificial tears may be effective at treating dry eye symptoms and that OTC artificial tears are generally safe, although not without side effects. This review analyzed many OTC artificial tear formulations, and most of the literature indicates uncertainty as to which OTC artificial tear works best. We searched for trials up to December 2015. We measured primary and secondary outcomes at two and four weeks, although we also considered other time points in this review. We recorded other commonly performed dry eye tests as secondary outcomes (e.g. We considered participant symptoms to be the primary outcome for this review. This review included 43 randomized controlled trials (3497 people with dry eye) that compared OTC artificial tears with other OTC artificial tears, with no treatment, or with placebo. Our review attempts to bridge this knowledge gap. There are a great number of commercially available artificial tears, yet there is currently no agreement about whether one formulation works better than another at treating dry eye. OTC artificial tears are meant to replace or supplement the tears (fluid) that naturally cover the eye’s front surface (cornea and conjunctiva). This condition affects millions of people around the world, and the first‐line treatment for dry eye is typically over the counter (OTC) artificial tears. What is the effect of over the counter (OTC) artificial tears on dry eye syndrome?ĭry eye syndrome is a long‐term condition that is known to cause eye discomfort and visual disturbances like blurred vision. Such lack of reporting of trial results represents a high risk of publication bias.Įfficacy of over the counter (OTC) artificial tears for dry eye syndrome These trials reportedly enrolled 2079 total participants for whom no data are available. Furthermore, we identified an additional 18 potentially eligible trials that were reported only in clinical trial registers with no associated results or publications. ![]() Overall, we assessed the quality of evidence as low due to high risks of bias among included trials and poor reporting of outcome measures which were insufficient for quantitative analysis. Our review also found that OTC artificial tears may be generally safe, but not without adverse events. All other included artificial tears produced contradictory between‐group results or found no between‐group differences. Nevertheless, we found that 0.2% polyacrylic acid‐based artificial tears were consistently more effective at treating dry eye symptoms than 1.4% polyvinyl alcohol‐based artificial tears in two trials assessing this comparison (175 participants). The review found that, in general, there was uncertainty whether different OTC artificial tears provide similar relief of signs and symptoms when compared with each other or placebo. Due to the heterogeneity of study characteristics among the included trials with respect to types of diagnostic criteria, interventions, comparisons, and measurements taken, our ability to perform meta‐analyses was limited. We included 43 randomized controlled trials (3497 participants with dry eye).
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